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KMID : 0380020190340010038
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Korean Journal of Biotechnology and Bioengineering
2019 Volume.34 No. 1 p.38 ~ p.48
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A Study on the Monitoring and Control of Bioprocesses Using LabVIEWTM
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Lee Seung-Hyun
Yim Yong-Sik
Rhee Jong-Il
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Abstract
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In this study, LabVIEWTM-based programs were developed for the monitoring and control of biological processes like recombinant E. coli fermentations. Electrical signals were obtained from sensors in the bioprocess and converted into values of process variables, and electrical noise was also eliminated. Dissolved oxygen concentrations during microbial fermentation were monitored and controlled using a PID control algorithm written in LabVIEWTM program. Fed-batch fermentations were performed using feedback and feedforward control techniques. Amounts of concentrated substrate entering to the bioreactor were graphically displayed and saved in a file as data. A two-dimensional fluorescence sensor was used to detect various biochemicals in biological processes. A LabVIEWTM program was developed for the monitoring of bioprocesses with the two-dimensional fluorescence sensor, and three-dimensional fluorescence spectra graphs were displayed in real-time via client PC. A flow injection analysis system (glucose-FIA) operated with a LabVIEWTM program was used for on-line monitoring of glucose in a bioprocess. Signal peaks obtained from the FIA detector were analyzed by the LabVIEWTM program, and peak graphs were saved in a file. On-line monitored glucose data were corresponded with off-line measured glucose data well.
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KEYWORD
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LabVIEWTM, biological process, 2D-fluorescence sensor, flow injection analysis, monitoring and control
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